Targeting protein modification: from chemical biology to drug discovery

Veranstaltungen
14:00 – 15:00
Medizinische Chemie
Dies ist ein Online Event
Prof. Dr. Ed Tate
Imperial College London and Francis Crick Institute
My group works on a wide range of chemical biology approaches focused primarily on small molecule probes that enable drug target identification and validation. Particularly active areas of research include conditional protein degradation, photoaffinity-driven target discovery, activity profiling of proteases and deubiquitinases, covalent fragment-based drug design, protein-protein interaction inhibitors, and chemical proteomic approaches to understand and target protein post-translational modifications. In this talk I will discuss our work in some of these areas, illustrated with examples of projects which have delivered small molecules into preclinical development.
Interessen

