Flow-based Peptide and Protein Synthesis
Veranstaltungen
16:00 – 17:00
Liebig-Vereinigung für Organische Chemie
Dies ist ein Online Event
Nina Hartrampf
University of Zurich
The field of biopharmaceuticals is rapidly expanding, requiring new methods for the on-demand production of chemically modified peptides and proteins. Chemical synthesis depends on efficient amide bond formation, with solid-phase peptide synthesis (SPPS) remaining the standard method for producing medium- to long-length peptides. However, yields often depend on the specific sequence, as peptide aggregation on the solid support can cause incomplete couplings in “difficult sequences.” Limited analytical tools have long hindered systematic study of this phenomenon. Flow-SPPS enables rapid synthesis and in-line analytics, offering insight into sequence-dependent aggregation. Aggregation phenomena are analyzed in detail, and novel computational, technological, and synthetic approaches are presented to minimize sequence dependence in SPPS.
Kontaktperson
Dr. Finn Burg
Zu Ihrem Kalender hinzufügen
Interessen
Veranstaltungsdetails
16:00 – 17:00
Liebig-Vereinigung für Organische Chemie
Dies ist ein Online Event
Nina Hartrampf
University of Zurich
Kontaktperson
Dr. Finn Burg
Zu Ihrem Kalender hinzufügen
