Pyrazole and its cyclic bio-isosteres can be used to afford promising lead molecules that have effective treatment of clinical illnesses. This review summarizes the recent developments in the medicinal chemistry aspect of pyrazole and its hybrid bio-isosteres-containing natural metabolites along with a thorough correlation between the therapeutic response and the structure-activity relationship.

Abstract

Natural products have been extensively explored for their role in drug design and development to eradicate numerous types of diseases. Also, heterocycles-based motifs are known to possess a wide range of therapeutic applications. Among them, pyrazole is a well-exploited scaffold by researchers in the different fields of medicinal chemistry. Recently, pharmacophoric hybridization became most urged approach in which two biologically active pharmacophoric skeletons tend to fuse together in any structural portion. Hence, pyrazole and its cyclic bio-isosteres may clubbed together to design and develop novel potent molecules against clinical disorders with least toxicity profile. In the present review, we aim to compile the numerous recent advancements in the medicinal chemistry of natural metabolites containing pyrazole and its bio-isosteres hybrid compounds with the following objectives: (1) To summarize the recent literature reports of last six years that are focused on the biological potential of natural pyrazole and its bio-isosteres hybrid derivatives; (2) To deliberate current developments in the medicinal aspect of natural compounds through their structural alteration by introducing pyrazole and its cyclic analogues; (3) To emphasize the complete correlation between structure activity relationship (SAR) and therapeutic response to disclose productive concepts for the generation of potential semi-synthetic candidates.