Artikel
TBAI‐catalyzed, TBHP‐mediated Modular Three‐Component Cascade towards Highly Functionalized Pyrrole via [3+2] Annulation
A facile, one-pot sequential synthesis of highly substituted pyrrole employing TBAI/TBHP has been developed from readily available precursors. β-Enaminones generated in situ from β-ketoesters and primary amines react sequentially with electron-deficient alkynes via a radical pathway to form the penta-substituted pyrroles in moderate to good yields. This strategy for the synthesis of highly functionalized pyrroles can be scaled up and shows tolerance to a variety of amines.
![TBAI‐catalyzed, TBHP‐mediated Modular Three‐Component Cascade towards Highly Functionalized Pyrrole via [3+2] Annulation](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.5ca6fc18.png&w=256&q=75)
![TBAI‐catalyzed, TBHP‐mediated Modular Three‐Component Cascade towards Highly Functionalized Pyrrole via [3+2] Annulation](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158444_fig_0001_a_36fd5c002c.png&w=256&q=75)
![TBAI‐catalyzed, TBHP‐mediated Modular Three‐Component Cascade towards Highly Functionalized Pyrrole via [3+2] Annulation](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158499_fig_0001_a_8463b1bf14.png&w=256&q=75)
![TBAI‐catalyzed, TBHP‐mediated Modular Three‐Component Cascade towards Highly Functionalized Pyrrole via [3+2] Annulation](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158504_gra_0001_a_6653df00f8.png&w=256&q=75)
