Artikel
Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy
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Herein, we report a novel and efficient synthetic strategy for the construction of poly-substituted imidazo[1,2-a]pyridines from the reaction of enaminonitriles with propargylamines via a domino conjugate substitution–nucleophilic addition-cycloisomerization process.
Abstract
A highly efficient domino process consisting of conjugate substitution, nucleophilic addition, and cycloisomerization from the reaction of enaminonitrile with propargylamine allowed for a successive double ring closure to afford a densely functionalized imidazo[1,2-a]pyridine through formation of three C─N bonds.
![Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.5ca6fc18.png&w=256&q=75)
![Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158444_fig_0001_a_36fd5c002c.png&w=256&q=75)
![Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158499_fig_0001_a_8463b1bf14.png&w=256&q=75)
![Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158504_gra_0001_a_6653df00f8.png&w=256&q=75)
