Photoinduced Cascade Cyclization of Ortho‐Alkynylanilines to Access Dithiocyanated or Selenocyanated Indoles
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Diverse indole derivatives are obtained by a cascade process involving dithiocyanation or selenocyanation and cyclization of ortho-alkynylanilines under mild conditions with NH4SCN/KSeCN. Experiments are undertaken to shed light on the radical reaction mechanism and investigate the versatility of the transformation.
A photoinduced cyclization and dithiocyanation/selenocyanation of ortho-alkynylanilines with NH4SCN/KSeCN provide various dithiocyanated and selenocyanated indoles. The structure of the indole framework is confirmed by single-crystal X-ray diffraction. In addition, a series of experiments investigating scale-up, other starting materials, and radical inhibition/capture are carried out to study the application and reaction process of this cascade system.
