Artikel
One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a ]quinolin‐5(6H )‐ones from 1‐(2‐Ethynylphenyl)‐1H ‐indoles
We present a method for the synthesis of substituted indolo[1,2-a]quinoline-5(6H)-ones starting from 1-(2-ethynylphenyl)-1H-indoles. The transformation involves gold-catalyzed oxidation of the triple bond followed by acid-promoted intramolecular cyclization at the indole C2 position. Demonstrating noteworthy versatility, the reaction tolerates a wide array of substituents on the indole core and proceeds in good to excellent yields (up to 93%).
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.5ca6fc18.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158444_fig_0001_a_36fd5c002c.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158499_fig_0001_a_8463b1bf14.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158504_gra_0001_a_6653df00f8.png&w=256&q=75)
