Artikel
Efficient Synthesis of 1,4‐Diazepines via Tf2O Promoted [5+2] Annulation of Ynamides with Imidazolidines
Von Wiley-VCH zur Verfügung gestellt
Efficient and Sustainable Strategy for the Synthesis of 1,4-Diazepines via [5 + 2] Annulation of Ynamides with Imidazolidines.
Abstract
A Tf2O-promoted [5+2] annulation of imidazolidines with ynamides has been developed, providing an efficient and sustainable strategy for the synthesis of 1,4-diazepines under the mild and metal-free conditions. A diverse of 6-aryl/alkyl substituted 5-amino-1,4-diazepines were formed in moderate to excellent yields. This transformation features with broad substrate scope, operational simplicity, environmental compatibility, and atomic economy. This protocol provides a sustainable alternative pathway for the synthesis of N-heterocycles.
![Efficient Synthesis of 1,4‐Diazepines via Tf2O Promoted [5+2] Annulation of Ynamides with Imidazolidines](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.5ca6fc18.png&w=256&q=75)
![Efficient Synthesis of 1,4‐Diazepines via Tf2O Promoted [5+2] Annulation of Ynamides with Imidazolidines](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158444_fig_0001_a_36fd5c002c.png&w=256&q=75)
![Efficient Synthesis of 1,4‐Diazepines via Tf2O Promoted [5+2] Annulation of Ynamides with Imidazolidines](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158499_fig_0001_a_8463b1bf14.png&w=256&q=75)
![Efficient Synthesis of 1,4‐Diazepines via Tf2O Promoted [5+2] Annulation of Ynamides with Imidazolidines](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158504_gra_0001_a_6653df00f8.png&w=256&q=75)
