Artikel
C(sp2)‐H Imination of Imidazo[1,2‐a]pyridines: A Catalyst‐Free, Multicomponent Approach
We have developed a one-pot, three-component strategy for the Friedel-Crafts arylation of α-imino ketones with imidazopyridines under catalyst-free conditions. The reaction did not require any inert conditions and proceeded at room temperature in the open flask.
Abstract
We report here a catalyst-free, (sp2)C−H imination reaction of in-situ formed imidazo[1,2-a]pyridines and α-iminoketones. This one-pot, multicomponent, and atom economic reaction is performed at moderate to room temperature without the need for any catalyst and inert conditions. The reaction showed good substrate tolerance with appreciable yields. Gram-scale synthesis and post-synthetic modifications to obtain 1,2-diketones are also described.
![C(sp2)‐H Imination of Imidazo[1,2‐a]pyridines: A Catalyst‐Free, Multicomponent Approach](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.5ca6fc18.png&w=256&q=75)
![C(sp2)‐H Imination of Imidazo[1,2‐a]pyridines: A Catalyst‐Free, Multicomponent Approach](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158444_fig_0001_a_36fd5c002c.png&w=256&q=75)
![C(sp2)‐H Imination of Imidazo[1,2‐a]pyridines: A Catalyst‐Free, Multicomponent Approach](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158499_fig_0001_a_8463b1bf14.png&w=256&q=75)
![C(sp2)‐H Imination of Imidazo[1,2‐a]pyridines: A Catalyst‐Free, Multicomponent Approach](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264158504_gra_0001_a_6653df00f8.png&w=256&q=75)
