Vortrag
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization
Veranstaltungen
05.12.23
16:00 – 17:00
Medizinische Chemie
Dies ist ein Online Event
Dr. Magnus Nilsson
AstraZeneca
JAK-STAT cytokines are critical in regulating immunity. Persistent activation of JAK-STAT signaling pathways by cytokines drives chronic inflammatory diseases such as asthma. The presentation will cover the discovery of a highly JAK1-selective, ATP-competitive series of inhibitors having a 1000-fold selectivity over other JAK family members and the approach used to identify compounds suitable for inhaled administration. Ultimately, AZD4604 was selected as the clinical candidate.
Kontaktperson
Dr. Felix Pape
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Interessen
Medizinische Chemie
Veranstaltungsdetails
05.12.23
16:00 – 17:00
Medizinische Chemie
Dies ist ein Online Event
Dr. Magnus Nilsson
AstraZeneca
Kontaktperson
Dr. Felix Pape
Zu Ihrem Kalender hinzufügen
In andere Kalender herunterladen
