Vortrag
Discovery of BI 1265162, an ENaC Inhibitor for the Treatment of Cystic Fibrosis
Veranstaltungen
26.01.22
15:00 – 16:00
Medizinische Chemie
Dies ist ein Online Event
Dr. Jörg Kley
Boehringer Ingelheim
BI 1265162 is an inhaled epithelial sodium channel (ENaC) inhibitor that reached clinical phase 2. This talk will discuss different approaches to achieve lung tissue selective ENaC inhibition and present how the structure of BI 1265162 evolved from a literature starting point. Besides the need for a long duration of action without renal side effects, physicochemical properties required for administration via the Respimat® Soft Mist™ inhaler guided our compound optimization.BI 1265162 contains a phosphine oxide moiety, and the properties brought in by this less common structural element are discussed.
Kontaktperson
Alexander Lorey
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Interessen
Medizinische Chemie
Veranstaltungsdetails
26.01.22
15:00 – 16:00
Medizinische Chemie
Dies ist ein Online Event
Dr. Jörg Kley
Boehringer Ingelheim
Kontaktperson
Alexander Lorey
Zu Ihrem Kalender hinzufügen
In andere Kalender herunterladen
