Dialkyl azodicarboxylates (DAAD) represent a significant class of organic compounds whose unique structure enables diverse applications in synthesis. Recognized for their role in the Mitsunobu reaction, these versatile reagents have evolved into tools for amination, oxidation, carbonylation, and cyclization processes. This review examines recent developments in DAAD chemistry, covering their applications in organic chemistry from 2019 onward.

Abstract

Dialkyl azodicarbixylates, characterized by the presence of an azo group (─N═N─) and two carboxyl groups, are an important class of organic compounds that have found wide application in organic synthesis, especially in Mitsunobu reaction. Their unique chemical properties make them irreplaceable tools for creating diverse molecular structures. This review provides an overview of key reactions involving dialkyl azodicarboxylates, highlighting their wide range of applications as reagents and catalysts. We also tried to demonstrate the immense potential of dialkyl azodicarboxylates in various types of reactions, including cross-coupling, redox processes, cycloaddition, cyclizations, and functionalization of aromatic systems. The versatility of dialkyl azodicarboxylates makes them a valuable tool for building complex molecular structures and expanding the possibilities of synthetic chemistry.