H Activation Assisted by N,O-Bidentate Directing Groups"/>

Transition-metal-catalyzed directing group-assisted CH functionalization, offers atom-economical routes to synthesize and functionalize complex molecules. This review covers recent advancements in N,O-bidentate directing group-assisted CO, CN, CS, CB, and CC bond formations, integrating mechanistic insights, diverse catalysts, and synthetic applications, emphasizing their profound impact on modern organic synthesis.

During the past decades, transition-metal-catalyzed CH functionalization has gained recognition as a powerful method in organic synthesis. This strategy provides efficient and atom-economical pathways for quickly creating molecular complexity by harnessing the abundant CH bonds found in readily accessible chemical feedstocks. Synthetic organic chemists discover directing group (DG)-assisted CH activation as a key tool for achieving efficient and site-selective CH functionalization. Bidentate directing groups are particularly effective in this regard, offering a high degree of control over the reaction site. Among various directing groups, N,O-bidentate systems have gained significant attention due to their strong coordinating ability and versatility in enabling regioselective transformations. This review highlights recent advances in CO, CN, CS, CB, and CC bond formation reactions facilitated by N,O-bidentate directing groups. The discussion encompasses mechanistic insights, catalyst systems, and synthetic applications, demonstrating the broad utility of these strategies in modern organic synthesis. A comparative analysis of different N,O-bidentate ligands and their role in tuning reactivity and selectivity is also presented.