Photoprotection is a current and relevant topic; therefore, the development of new sunscreens is necessary. To this end, nature is examined for molecules such as mycosporine-like amino acids and gadusol. Through rational design, this study has successfully synthesized new UV filters and evaluated their photoprotective and antioxidant properties.

Photoprotection is a crucial strategy for preventing the harmful effects of ultraviolet (UV) radiation on human skin, including sunburn, photoaging, and skin cancer. Currently, there is a growing need to develop more sustainable UV filters, as the existing ones may pose environmental risks. In addition to UV protection, cosmetic formulations incorporate antioxidants such as ascorbic acid to neutralize the free radicals generated by UV radiation, helping to reduce the oxidative stress and DNA damage caused. Addressing this challenge, this study explores analogs of naturally absorbing molecules (mycosporine-like amino acids and gadusol) as potential eco-friendly UV filters. These compounds, found in marine organisms, exhibit strong UV absorption and antioxidant properties while being less harmful to aquatic ecosystems. Structural analogs of these molecules are synthesized and evaluated to assess their efficacy as novel UV filters. The findings suggest that these bioinspired compounds provide effective photoprotection, photostability, and safety, and their research and development could contribute to safer and more sustainable cosmetic formulations.